In the world of email delivery, your IP address reputation is what it's all about. In days past, all you had to do was ensure that the emails going out of your system were clean, and the spam filters would pass them through into inboxes. Now, Internet Service Providers keep volumes of data on your IP addresses and what kind of email you send through them. They also keep data on frequency, volume, bounce count, and spam complaints.
In order to optimize email deliverability, one must not only ensure that emails have non-spam-like content, but also that one keeps bounce counts and complaints low: if your IP drops e-mail to 10,000 bogus Yahoo addresses, Yahoo's going to assume the other 10,000 good addresses are receiving junk and handle it accordingly. Our member organizations control the first part of that equation, and (by being ethical mailers and not uploading spam lists) a portion of the second.
But a very big part of keeping bounce counts and spam complaints within ISPs' operational limits happens out of DIA's shop through processes to automatically unsubscribe addresses that have gone sour.